Review documents

For information and general research information on nitric oxide and its medical uses, the reader is referred to the following books and recent review articles: CAUTION: This information concerns uses that have not been approved or cleared by the U.S. Food and Drug Administration.

  • Inhaled nitric oxide reduces secondary brain damage after traumatic brain injury in mice, Tepolilli NA, Kim SW, Thal SC, Kuebler WM, Plesnila N. J of Cerebral Blood Flow and Met.2013; 33,311-318.
  • Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?, Papadimos TJ, Medhour A, Yermal S, Scandinavian J of Trauma, Res and E Med 2009, 17-5 doi:10.1189/1757-7211.
  • J Infect Dis. 2013 May 15;207(10):1576-84. doi: 10.1093/infdis/jit062. Epub 2013 Feb 18. Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice. Perrone LA1, Belser JA, Wadford DA, Katz JM, Tumpey TM.
  • Bench-to-bedside review: Inhaled nitric oxide therapy in adults, Creagh-Brown BC, Griffiths MJ, Evans TW, Crit. Care. 2009;13(3):221.
  • Nitric oxide mechanism of protection in ischemia and reperfusion injury, Phillips L, Toledo AH, Lopez-Neblina F, Anaya-Prado R, Toledo-Pereyra LH., J Invest Surg. 2009 Jan-Feb;22(1):46-55.
  • Inhaled Nitric Oxide Reduces Endothelial Activation and Parasite Accumulation in the Brain, and Enhances Survival in Experimental Cerebral Malaria, Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, WC Liles, Zapol WM, Kain KC LiPLoS ONE 6(11): e27714. doi:10.1371/journal.pone.0027714
  • Nitric oxide: a newly discovered function on wound healing,Luo J,Chen AF, ActaPharmcologica Sinica. 2005 Feb; DOI: 10.1111/j.1745-7254.2005.00058.x
  • Role of iNO in the modulation of pulmonary vascular resistance, Bin-Nun A, Schreiber MD. J Perinatol. 2008 Dec;28 Suppl 3:S84-92.
  • Inhaled nitric oxide therapy, Okamoto K, Kitamura M, Kikuchi T, Mochizuki K, Nituta K, Nippon Rinsho. 2008 Nov; 66(11):2169-73.Review. Japanese. PMID.
  • Long-term inhaled nitric oxide plus phosphodiesterase 5 inhibitors for severe pulmonary hypertension, Perez-Penate GM, Julia-Serida G, Ojeda-Betancort N, Garcia-Quintana, A, Pulido-Duque J, Rodriguez-Perez A, Cabera-Navarro P, Gomez-Sanchez MA, J Heart Lung Transplant 2008; 27(12):1326-1332.
  • Inhaled nitric oxide for acute chest syndrome in people with sickle cell disease, Al Hajeri A, Serjeant GR, Fedorowicz Z: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006957.
  • Sars coronavirus : The role of accessory proteins and nitric oxide in the replication cycle, S Akerstrom, Institutionen for mikrobiologi, tumor- och cellbiologi / Department of Microbiology, Tumor and Cell Biolog, Publication year: 2008;ISBN: 978-91-7409-086-4
  • J Virol. 2005 Feb;79(3):1966-9. Nitric oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus. Akerstrom S1, Mousavi-Jazi M, Klingstrom J, Leijon M, Lundkvist A, Mirazimi A.
  • J Virol. 2004 Feb;78(3):1564-74. Astrovirus-induced synthesis of nitric oxide contributes to virus control during infection. Koci MD1, Kelley LA, Larsen D, Schultz-Cherry S.
  • Curr Opin Allergy Clin Immunol. 2005 Feb;5(1):37-42. Nitric oxide and the common cold. Proud D.
  • The role of nitric oxide in the pathophysiology of intimal hyperplasia, Ahanchi SS, Tsihlis ND, Kibbe MR, J Vasc Surg. 2007 Jun; 45 Suppl A:A64-73.Review.
  • Inhaled NO as a therapeutic agent, Bloch KD, Ichinose F, Roberts JD Jr, Zapol WM; Cardiovasc Res.2007 Jul 15;75(2):339-48. Epub 2007 May 4.
  • J Gen Virol. 2006 Oct;87(Pt 10):3003-11. Antiviral action of nitric oxide on dengue virus type 2 replication. Takhampunya R1, Padmanabhan R, Ubol S.
  • Int J Exp Pathol. Apr 2000; 81(2): 165-172. doi: 10.1046/j.1365-2613.2000.00148.x PMCID: PMC2517721 Antiviral effect of nitric oxide during Japanese encephalitis virus infection Shailendra K Saxena, Aditi Singh, and Asha Mathur
  • Responsiveness to inhaled nitric oxide is a predictor for mid-term survival in adult patients with congenital heart defects and pulmonary arterial hypertension, Post MC, Janssens, S, Van de Werf F, Budts W, Eur Heart J 2004;25:1651-1656.
  • Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD, Vonbank K, Ziesche R, Higgenbottam TW, Steibellehner L, Petkov V, Schneck P, Germann P, Block LH, Thorax 2003;58:289-293.
  • Use of nitric oxide inhalation in chronic obstructive pulmonary disease, Ashutosh K, Phadke K, Jackson JF, Steele D, Thorax 2000;55:109-113.
  • Nitric Oxide Biology and Pathobiology (2000), Editor Louis J Ignarro, Academic Press.
  • Nitric Oxide and the Regulation of the Peripheral Circulation (2000), Editor Philip J Kadowitz and Dennis B. McNamara, Brikhauser Press.
  • J Virol. 1999 Oct;73(10):8880-3. Inhibition of influenza virus replication by nitric oxide. Rimmelzwaan GF1, Baars MM, de Lijster P, Fouchier RA, Osterhaus AD.
  • The effect of low-dose inhalation of nitric oxide in patients with pulmonary fibrosis, Yoshida M, Taguchi O, Gabazza EC, Yasui H, Kobayashi T, Kobayashi H, Maruyama K, Adachi Y, Eur Respir J 1997;10:2051-2054.
  • Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension, Channick RN, Johnson FW, Willians PJ, Auger WR, Fedullo PF, Moser KM Newhart JW, Chest 1996;109:1545-1549.